Overview

Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.

With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world's leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world's deadliest diseases and make life beyond cancer a reality.

At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems.

The Subramaniam lab seeks a Postdoctoral Research Fellow to investigate mechanisms of human mRNA translation. We recently developed ReLiC, a high throughput CRISPR screening approach to identify regulators of translation and other RNA metabolic processes in human cells (Nugent et al. Nature Methods 2025). Current projects leverage ReLiC to dissect cellular pathways regulating global and mRNA-specific translation in healthy and diseased human cells.

Environment:

The Subramaniam lab is part of the Basic Sciences Division and the Computational Biology Program at Fred Hutch. More information on the Subramaniam lab can be found at http://rasilab.github.io. A manual describing roles, expectations, and lab policies can be found at https://rasilab.github.io/docs/lab_manual.

Candidates are required to submit a CV and a cover letter. The cover letter should specifically address why your background is a good fit for the Subramaniam lab, and it should outline one or two ideas for potential research projects. Applications without a cover letter will not be considered further.

Responsibilities

• Master cutting-edge deep sequencing technologies to identify cellular factors regulating human mRNA translation
• Apply computational and machine learning methods to analyze high-throughput datasets
• Use targeted biochemical and genetic approaches to characterize mRNA sequence motifs and regulatory factors
• Develop an independent research project leveraging your unique expertise
• Present findings at conferences and prepare manuscripts for publication

Qualifications

MINIMUM QUALIFICATIONS:

• PhD in relevant field with expertise in biochemical/genetic approaches to study cellular processes
• Strong interest in learning high-throughput sequencing and computational approaches
• Independent work ethic and excellent communication skills

PREFERRED QUALIFICATIONS:

• Experience with mammalian cell models of development or disease
• Background that complements our research program

Candidates are required to submit a CV and a cover letter. The cover letter should specifically address why your background is a good fit for the Subramaniam lab, and it should outline one or two ideas for potential research projects. Applications without a cover letter will not be considered further.

The annual base salary range for this position is from $77,976 to $95,014, and pay offered will be based on experience and qualifications. This position may be eligible for relocation assistance.

This position is not eligible for immigration sponsorship. Applicants must already be authorized to work in the US and not require sponsorship now or in the future.Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, tuition reimbursement, paid vacation (22 days per year), paid sick leave (up to 30 calendar days per occurrence of a qualifying reason), paid holidays (up to 13 days per year), paid parental leave (up to 4 weeks), and partially paid sabbatical leave (up to 12 months for professor track faculty, up to 6 months for other scientific staff).

Additional Information